Molecular modeling reveals binding interface of γ‐tubulin with GCP4 and interactions with noscapinoids

  title={Molecular modeling reveals binding interface of $\gamma$‐tubulin with GCP4 and interactions with noscapinoids},
  author={Charu Suri and Harish C. Joshi and Pradeep Kumar Naik},
  journal={Proteins: Structure},
The initiation of microtubule assembly within cells is guided by a cone shaped multi‐protein complex, γ‐tubulin ring complex (γTuRC) containing γ‐tubulin and atleast five other γ‐tubulin‐complex proteins (GCPs), i.e., GCP2, GCP3, GCP4, GCP5, and GCP6. The rim of γTuRC is a ring of γ‐tubulin molecules that interacts, via one of its longitudinal interfaces, with GCP2, GCP3, or GCP4 and, via other interface, with α/β−tubulin dimers recruited for the microtubule lattice formation. These… 
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    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
  • 2020
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