Molecular modeling of CD28 and three-dimensional analysis of residue conservation in the CD28/CD152 family.

@article{Bajorath1997MolecularMO,
  title={Molecular modeling of CD28 and three-dimensional analysis of residue conservation in the CD28/CD152 family.},
  author={J{\"u}rgen Bajorath and William J. Metzler and Peter S. Linsley},
  journal={Journal of molecular graphics & modelling},
  year={1997},
  volume={15 2},
  pages={135-9, 108-11}
}
CD28/CD152-CD80/CD86 receptor-ligand interactions result in costimulatory signals critical for optimal T cell activation. CD28/CD152 and CD80/CD86 are members of the immunoglobulin superfamily (IgSF). Despite common receptor-ligand interactions, both receptor and ligand pairs share only limited sequence identity. A detailed molecular model of the extracellular Ig-like domain of human CD28 was constructed using a combination of different modeling methods. The model was based on the solution… CONTINUE READING
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