Molecular modeling of 2-alkyloxy- and 2-aralkyloxy-adenosine A1- and A2-agonists.


The C2-region of adenosine A1- and A2-receptors by a molecular modeling technique has been extended and applied to a series of 2-substituted adenosines reported by Olsson, et al. The similarity and dissimilarity of the structure maps obtained by molecular modeling have been used as a basis for the mapping of the analysed receptor domain. The proposed model… (More)


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