Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex.

@article{Horsten1997MolecularMM,
  title={Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex.},
  author={Ursula Horsten and G M{\"u}ller-newen and Claudia Gerhartz and Axel Wollmer and John Wijdenes and Peter Claus Heinrich and Joachim Gr{\"o}tzinger},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 38},
  pages={23748-57}
}
The transmembrane protein gp130 is involved in many cytokine-mediated cellular responses and acts therein as the signal-transducing subunit. In the case of interleukin-6 (IL-6), the signal-transducing complex is composed of the ligand IL-6, the IL-6 receptor (IL-6R, gp80, CD126), and at least two gp130 (CD130) molecules. The extracellular part of the signal transducer gp130 consists of six fibronectin type III-like domains. It has recently been shown that the three membrane distal domains bind… CONTINUE READING

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