Molecular modeling and spectroscopic studies of semustine binding with DNA and its comparison with lomustine–DNA adduct formation

@article{Agarwal2015MolecularMA,
  title={Molecular modeling and spectroscopic studies of semustine binding with DNA and its comparison with lomustine–DNA adduct formation},
  author={Shweta Agarwal and Deepti Chadha and Ranjana Mehrotra},
  journal={Journal of Biomolecular Structure and Dynamics},
  year={2015},
  volume={33},
  pages={1653 - 1668}
}
Chloroethyl nitrosoureas constitute an important family of cancer chemotherapeutic agents, used in the treatment of various types of cancer. They exert antitumor activity by inducing DNA interstrand cross-links. Semustine, a chloroethyl nitrosourea, is a 4-methyl derivative of lomustine. There exist some interesting reports dealing with DNA-binding properties of chloroethyl nitrosoureas; however, underlying mechanism of cytotoxicity caused by semustine has not been precisely and completely… 

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