Molecular modeling and site-specific mutagenesis of the histamine-binding site of the histamine H4 receptor.

  title={Molecular modeling and site-specific mutagenesis of the histamine-binding site of the histamine H4 receptor.},
  author={Niu Shin and Elizabeth Coates and Nicholas Murgolo and K Morse and Marvin L. Bayne and Catherine D. Strader and Frederick J. Monsma},
  journal={Molecular pharmacology},
  volume={62 1},
The histamine H4 receptor is a novel G-protein-coupled receptor with a unique pharmacological profile. The distribution of H4 mRNA suggests that it may play a role in the regulation of immune function, particularly with respect to allergy and asthma. To define the histamine-binding site of this receptor, molecular modeling and site-directed mutagenesis were used to predict and alter amino acids residing in the histamine-binding pocket. The effects of these alterations on histamine binding and… 

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