Molecular modeling and mutagenesis of gap junction channels.

  title={Molecular modeling and mutagenesis of gap junction channels.},
  author={Julio A. Kovacs and Kent A. Baker and Guillermo A Altenberg and Ruben Abagyan and Mark Yeager},
  journal={Progress in biophysics and molecular biology},
  volume={94 1-2},
Gap junction channels connect the cytoplasms of adjacent cells through the end-to-end docking of hexameric hemichannels called connexons. Each connexon is formed by a ring of 24 alpha-helices that are staggered by 30 degrees with respect to those in the apposed connexon. Current evidence suggests that the two connexons are docked by interdigitated, anti-parallel beta strands across the extracellular gap. The second extracellular loop, E2, guides selectivity in docking between connexons formed… CONTINUE READING
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