Molecular modeling, mutational analysis and conformational switching in IL27: An in silico structural insight towards AIDS research.

@article{Banerjee2016MolecularMM,
  title={Molecular modeling, mutational analysis and conformational switching in IL27: An in silico structural insight towards AIDS research.},
  author={Arundhati Banerjee and Sujay Ray},
  journal={Gene},
  year={2016},
  volume={576 1 Pt 1},
  pages={
          72-8
        }
}
The advancement in proteomics and bioinformatics provokes to discern the molecular-level probe for HIV inhibitor; human interleukin-27 (IL27). Documentation documents that tyrosine residues in IL27 play a pivotal role for interacting with HIV, causing apoptosis of the HIV+ cells. Primarily, 3D structure of human wild-type (WT) IL27 was built through manifold molecular modeling techniques after the satisfaction of stereo-chemical properties. Its essential tyrosine residues were identified. Two… CONTINUE READING
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