Molecular model of hemoglobin N from Mycobacterium tuberculosis bound to lipid bilayers: a combined spectroscopic and computational study.

@article{Rhault2015MolecularMO,
  title={Molecular model of hemoglobin N from Mycobacterium tuberculosis bound to lipid bilayers: a combined spectroscopic and computational study.},
  author={Jean-François Rh{\'e}ault and {\`E}ve Gagn{\'e} and Michel Guertin and Guillaume Lamoureux and Mich{\`e}le Auger and Patrick Lag{\"u}e},
  journal={Biochemistry},
  year={2015},
  volume={54 11},
  pages={
          2073-84
        }
}
A singular aspect of the 2-on-2 hemoglobin structures of groups I and II is the presence of tunnels linking the protein surface to the distal heme pocket, supporting the storage and the diffusion of small apolar ligands to/from the buried active site. As the solubility of apolar ligands is greater in biological membranes than in solution, the association of these proteins with biological membranes may improve the efficiency of ligand capture. As very little is known on this subject, we have… Expand
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