Molecular mode of action of CGS 9895 at α1 β2 γ2 GABAA receptors.

@article{Maldifassi2016MolecularMO,
  title={Molecular mode of action of CGS 9895 at α1 β2 γ2 GABAA receptors.},
  author={Maria Constanza Maldifassi and Roland Baur and Erwin Sigel},
  journal={Journal of neurochemistry},
  year={2016},
  volume={138 5},
  pages={
          722-30
        }
}
γ-aminobutyric type A (GABAA ) receptors are the main inhibitory neurotransmitter receptors in the brain and are targets for numerous clinically important drugs such as benzodiazepines, anxiolytics, and anesthetics. Previously, pyrazoloquinoline 2-p-methoxyphenylpyrazolo [4,3-c] quinolin-3(5H)-one (CGS 9895) was described as a positive allosteric modulator acting through the α+/β- interface in the extracellular domain of GABAA receptors. The localization of the binding site was based on a… CONTINUE READING
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