Molecular mimicry of the NF-kappaB DNA target site by a selected RNA aptamer.

@article{Ghosh2004MolecularMO,
  title={Molecular mimicry of the NF-kappaB DNA target site by a selected RNA aptamer.},
  author={Gourisankar Ghosh and D Huang and T. J. Huxford},
  journal={Current opinion in structural biology},
  year={2004},
  volume={14 1},
  pages={21-7}
}
During the past two decades, structural and biophysical studies of DNA-protein and RNA-protein complexes have enhanced our understanding of the physico-chemical basis of nucleic acid recognition by proteins. However, it remains unclear what protein surface features are most important for nucleic acid binding and whether the same protein surface could bind specifically to both DNA and RNA. The recently described X-ray crystal structure of the transcription factor NF-kappaB p50 homodimer bound to… CONTINUE READING
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