Molecular mimicry of human tRNALys anti-codon domain by HIV-1 RNA genome facilitates tRNA primer annealing.

@article{Jones2013MolecularMO,
  title={Molecular mimicry of human tRNALys anti-codon domain by HIV-1 RNA genome facilitates tRNA primer annealing.},
  author={Christopher P Jones and Jenan Saadatmand and Lawrence S. Kleiman and Karin Musier-Forsyth},
  journal={RNA},
  year={2013},
  volume={19 2},
  pages={219-29}
}
The primer for initiating reverse transcription in human immunodeficiency virus type 1 (HIV-1) is tRNA(Lys3). Host cell tRNA(Lys) is selectively packaged into HIV-1 through a specific interaction between the major tRNA(Lys)-binding protein, human lysyl-tRNA synthetase (hLysRS), and the viral proteins Gag and GagPol. Annealing of the tRNA primer onto the complementary primer-binding site (PBS) in viral RNA is mediated by the nucleocapsid domain of Gag. The mechanism by which tRNA(Lys3) is… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 8 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Exploiting tRNAs to Boost Virulence.

View 3 Excerpts
Highly Influenced

Emergence and evolution.

Topics in current chemistry • 2014
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 66 references

Structural and functional diversity of viral IRESes

L Balvay, R SotoRifo, EP Ricci, D Decimo, T Ohlmann
Biochim Biophys Acta • 2009
View 8 Excerpts
Highly Influenced

A human aminoacyl-tRNA synthetase as a regulator of angiogenesis.

Proceedings of the National Academy of Sciences of the United States of America • 2002
View 4 Excerpts
Highly Influenced

- like structures

D Heacock, C Forsyth, K Shiba, K Musier-Forsyth
1996
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…