Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells

@article{Aliberti2003MolecularMO,
  title={Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells},
  author={J{\'u}lio C. S. Aliberti and Jesus G Valenzuela and Vern B Carruthers and Sara Hieny and John Andersen and Hugues Charest and Caetano Reis e Sousa and Alan H. Fairlamb and J M C Ramalho Ribeiro and Alan Sher},
  journal={Nature Immunology},
  year={2003},
  volume={4},
  pages={485-490}
}
Toxoplasma gondii releases factors that potently stimulate production of interleukin-12 (IL-12) from dendritic cells (DCs). Purification of this activity showed that cyclophilin-18 (C-18) was its principal component, and antibodies generated against recombinant C-18 inhibited tachyzoite extract–induced synthesis of IL-12. Recombinant C-18 showed high affinity for and triggered cell signaling through CCR5, a chemokine receptor important in parasite-induced IL-12 production by DCs. These findings… CONTINUE READING
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