Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease

@article{Guilherme2006MolecularMI,
  title={Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease},
  author={Luiza Guilherme and Jorge Kalil and Madeleine W. Cunningham},
  journal={Autoimmunity},
  year={2006},
  volume={39},
  pages={31 - 39}
}
Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the α-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with streptococcal M protein and cardiac myosin. Recent studies have unraveled the potential pathogenic mechanisms by which the immune response against the group A streptococcus attacks the… Expand

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