Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease

@article{Guilherme2006MolecularMI,
  title={Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease},
  author={L. Guilherme and J. Kalil and M. Cunningham},
  journal={Autoimmunity},
  year={2006},
  volume={39},
  pages={31 - 39}
}
  • L. Guilherme, J. Kalil, M. Cunningham
  • Published 2006
  • Biology, Medicine
  • Autoimmunity
  • Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the α-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with streptococcal M protein and cardiac myosin. Recent studies have unraveled the potential pathogenic mechanisms by which the immune response against the group A streptococcus attacks the… CONTINUE READING

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
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    ConditionsObsessive Compulsive Disorder (OCD), PANDAS, PANS
    InterventionDrug
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    Genes, autoimmunity and pathogenesis of rheumatic heart disease
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    Towards a Vaccine Against Rheumatic Fever
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