Molecular mimicry: its evolution from concept to mechanism as a cause of autoimmune diseases.

@article{Oldstone2014MolecularMI,
  title={Molecular mimicry: its evolution from concept to mechanism as a cause of autoimmune diseases.},
  author={Michael B A Oldstone},
  journal={Monoclonal antibodies in immunodiagnosis and immunotherapy},
  year={2014},
  volume={33 3},
  pages={158-65}
}
On a clonal level, certain antibodies and T cells can interact with dissimilar antigens found in microbes and in host cells. More than 5% of over 800 monoclonal antibodies derived from multiple RNA and DNA viruses, as well as from a large number of T cell clones, engage in such interactions. Several of these cross-reactions, which we termed molecular mimicry, are against unique host proteins involved in autoimmune responses and diseases. Thus, molecular mimicry initiated as a host response to a… CONTINUE READING

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