Molecular medicine of microRNAs: structure, function and implications for diabetes.

@article{Hennessy2008MolecularMO,
  title={Molecular medicine of microRNAs: structure, function and implications for diabetes.},
  author={Erica Hennessy and Lorraine O'Driscoll},
  journal={Expert reviews in molecular medicine},
  year={2008},
  volume={10},
  pages={e24}
}
MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19-28 nucleotides in length. In humans, up to 3% of all genes are estimated to encode these evolutionarily conserved sequences. miRNAs are thought to control expression of thousands of target mRNAs. Mammalian miRNAs generally negatively regulate gene expression by repressing translation, possibly through effects on mRNA stability and compartmentalisation, and/or the translation process itself. An extensive range of… CONTINUE READING