Molecular mediators, environmental modulators and experience-dependent synaptic dysfunction in Huntington's disease.

@article{Hannan2004MolecularME,
  title={Molecular mediators, environmental modulators and experience-dependent synaptic dysfunction in Huntington's disease.},
  author={Anthony J Hannan},
  journal={Acta biochimica Polonica},
  year={2004},
  volume={51 2},
  pages={415-30}
}
Huntington's disease (HD) is an autosomal dominant disorder in which there is progressive neurodegeneration producing motor, cognitive and psychiatric symptoms. HD is caused by a trinucleotide (CAG) repeat mutation, encoding an expanded polyglutamine tract in the huntingtin protein. At least eight other neurodegenerative diseases are caused by CAG/glutamine repeat expansions in different genes. Recent evidence suggests that environmental factors can modify the onset and progression of… CONTINUE READING
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