Molecular mechanisms.

  title={Molecular mechanisms.},
  author={Steven C. Hebert},
  journal={Seminars in nephrology},
  volume={19 6},
The clinically useful and potent distal acting diuretics enhance urinary NaCl excretion by specific inhibition of distinct sodium transport processes in the loop of Henle and distal nephron. When these compounds were first used as diuretics little was known about their cellular mechanisms of action. Physiological investigations over the past 25 years, however, have shown that each class of diuretics inhibits a specific ion transport system in the kidney. Over the past few years, the molecular… CONTINUE READING