Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates.

@article{Chang2014MolecularMU,
  title={Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates.},
  author={Tammy Chang and Millie Hughes-Fulford},
  journal={Biomaterials},
  year={2014},
  volume={35 7},
  pages={2162-71}
}
Three-dimensional (3D) culture of hepatocytes leads to improved and prolonged synthetic and metabolic functions, but the underlying molecular mechanisms are unknown. In order to investigate the role of 3D cell-cell interactions in maintaining hepatocyte differentiated functions ex vivo, primary mouse hepatocytes were cultured either as monolayers on tissue culture dishes (TCD) or as 3D aggregates in rotating wall vessel (RWV) bioreactors. Global gene expression analyses revealed that genes… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 70 references

3 D spheroid culture of hESC / hiPSCderived hepatocytelike cells for drug toxicity testing

  • K Takayama, K Kawabata, Y Nagamoto, K Kishimoto, K Tashiro, F Sakurai
  • Biomaterials
  • 2012

Similar Papers

Loading similar papers…