Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer

@inproceedings{Wadosky2016MolecularMU,
  title={Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer},
  author={Kristine M. Wadosky and Shahriar Koochekpour},
  booktitle={Oncotarget},
  year={2016}
}
Prostate cancer (PCa) is the most widely diagnosed male cancer in the Western World and while low- and intermediate-risk PCa patients have a variety of treatment options, metastatic patients are limited to androgen deprivation therapy (ADT). This treatment paradigm has been in place for 75 years due to the unique role of androgens in promoting growth of prostatic epithelial cells via the transcription factor androgen receptor (AR) and downstream signaling pathways. Within 2 to 3 years of ADT… CONTINUE READING
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