Molecular mechanisms underlying oxytocin-induced cardiomyocyte protection from simulated ischemia–reperfusion

@article{GonzalezReyes2015MolecularMU,
  title={Molecular mechanisms underlying oxytocin-induced cardiomyocyte protection from simulated ischemia–reperfusion},
  author={Araceli Gonzalez-Reyes and Ahmed M{\'e}naouar and Denis Yip and Bogdan Alexandru Danalache and Marek Jankowski},
  journal={Molecular and Cellular Endocrinology},
  year={2015},
  volume={412},
  pages={170-181}
}

The Role of Oxytocin in Cardiovascular Protection

Evidence indicates that oxytocin treatment improves cardiac work, reduces apoptosis and inflammation, and increases scar vascularization, as well as cardioprotection, by reducing the inflammatory response and improving cardiovascular and metabolic function.

Oxytocin maintains lung histological and functional integrity to confer protection in heat stroke

The data indicate that OT pretreatment can reduce the ischemic, inflammatory and oxidative responses related to heat-induced ALI in rats.

Oxytocin and cardioprotection in diabetes and obesity

It is shown that chronic OT treatment prevents the development of diabetic cardiomyopathy in the db/db mouse and may help replace lost CMs by stimulating the in situ differentiation of cardiac stem cells into functional mature CMs.

Oxytocin-induced endothelial nitric oxide dependent vasorelaxation and ERK1/2-mediated vasoconstriction in the rat aorta

Oxytocin stimulation of PI3K/eNOS-derived nitric oxide may participate in maintenance of cardiovascular homeostasis, and different vascular reactivities to low or high dose of oxytocin suggest that Oxytocin may have different regulatory effects on vascular tone under physiological or pathophysiological conditions.

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