Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation.

Abstract

The rapid atrial rate during atrial fibrillation (AF) decreases the ionic current density of transient outward K+ current, L-type Ca2+ current, and Na+ current, thereby altering cardiac electrophysiology and promoting arrhythmia maintenance. To assess possible underlying changes in cardiac gene expression, we applied competitive reverse transcriptase… (More)

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@article{Yue1999MolecularMU, title={Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation.}, author={Lixia Yue and Peter C. Melnyk and Rania Gaspo and Zheng Wang and Stanley Nattel}, journal={Circulation research}, year={1999}, volume={84 7}, pages={776-84} }