Molecular mechanisms underlying effects of epidermal growth factor receptor inhibition on invasion, proliferation, and angiogenesis in experimental glioma.

@article{Guillamo2009MolecularMU,
  title={Molecular mechanisms underlying effects of epidermal growth factor receptor inhibition on invasion, proliferation, and angiogenesis in experimental glioma.},
  author={Jean S{\'e}bastien Guillamo and Sophie de Bo{\"u}ard and Samuel Valable and L{\'e}na Marteau and Pascal Leuraud and Yannick Marie and M Poupon and J-J Parienti and Eric Raymond and Marc Peschanski},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 11},
  pages={3697-704}
}
PURPOSE Epidermal growth factor receptor (EGFR) signal transduction pathways are implicated in malignant glioma aggressiveness and promote tumor cell invasion, proliferation, and angiogenesis. Nevertheless, response to EGFR tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) has been disappointing in clinical trials. One potential explanation may come from the diversity of molecular alterations seen in gliomas. To validate that hypothesis, we have investigated responses to gefitinib on various… CONTINUE READING