Molecular mechanisms regulating myelination in the peripheral nervous system.

  title={Molecular mechanisms regulating myelination in the peripheral nervous system.},
  author={Jorge A. Pereira and Fr{\'e}d{\'e}ric Lebrun-Julien and Ueli Suter},
  journal={Trends in neurosciences},
  volume={35 2},
Glial cells and neurons are engaged in a continuous and highly regulated bidirectional dialog. A remarkable example is the control of myelination. Oligodendrocytes in the central nervous system (CNS) and Schwann cells (SCs) in the peripheral nervous system (PNS) wrap their plasma membranes around axons to organize myelinated nerve fibers that allow rapid saltatory conduction. The functionality of this system is critical, as revealed by numerous neurological diseases that result from… CONTINUE READING
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