Molecular mechanisms regulating NETosis in infection and disease

  title={Molecular mechanisms regulating NETosis in infection and disease},
  author={Nora Branzk and Venizelos Papayannopoulos},
  booktitle={Seminars in Immunopathology},
Neutrophils are the foot soldiers of the immune system. They home in to the site of infection and kill pathogens by phagocytosis, degranulation, and the release of web-like structures called neutrophil extracellular traps (NETs) that trap and kill a variety of microbes. NETs have been shown to play a multitude of additional roles in immunity but have also been implicated in inflammatory and autoimmune disease. Here, we discuss the role of NETs in these various contexts with a particular… CONTINUE READING
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