Molecular mechanisms of tumor-bone interactions in osteolytic metastases.

  title={Molecular mechanisms of tumor-bone interactions in osteolytic metastases.},
  author={John M. Chirgwin and Theresa A. Guise},
  journal={Critical reviews in eukaryotic gene expression},
  volume={10 2},
In patients with advanced disease, several cancer types frequently metastasize to the skeleton, where they cause bone destruction. Osteolytic metastases are incurable and cause pain, hypercalcemia, fracture, and nerve compression syndromes. It was proposed over a century ago that certain cancers, such as that of the breast, preferentially metastasize to the favorable microenvironment provided by bone. Bone matrix is a rich store of immobilized growth factors that are released during bone… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 83 extracted citations

Breast cancer at bone metastatic sites: recent discoveries and treatment targets

Journal of Cell Communication and Signaling • 2011
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…