Molecular mechanisms of the polymerization of fibrin and the formation of its three-dimensional network

@article{Lugovskoi2009MolecularMO,
  title={Molecular mechanisms of the polymerization of fibrin and the formation of its three-dimensional network},
  author={Eduard Lugovskoi and Pavel Gritsenko and Serhey V Komisarenko},
  journal={Russian Journal of Bioorganic Chemistry},
  year={2009},
  volume={35},
  pages={393-410}
}
The results of biochemical, immunochemical, and X-ray studies of the structures of fibrinogen and fibrin molecules were analyzed. The mechanisms of the successive formation of the fibrin three-dimensional network were described: the polymerization of monomeric molecules with the formation of bifilar protofibrils, the lateral association of protofibrils, and the embranchment of the forming fibrils. Data on the electron and confocal microscopy of the polymeric fibrin were considered. The role of… CONTINUE READING

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