Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at gamma-aminobutyric acid type A receptor.

@article{Puia1992MolecularMO,
  title={Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at gamma-aminobutyric acid type A receptor.},
  author={G. Puia and I. Duci{\'c} and S. Vicini and E. Costa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89},
  pages={3620 - 3624}
}
  • G. Puia, I. Ducić, +1 author E. Costa
  • Published 1992
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
In central nervous system gamma-aminobutyric acid (GABA) inhibits neuronal activity by acting on GABA type A (GABAA) receptors. These heterooligomeric integral membrane proteins include a GABA-gated Cl- channel and various allosteric modulatory sites where endogenous modulators and anxiolytic drugs act to regulate GABA action. In vivo, various anxiolytic drugs exhibit a wide range of variability in their modulatory efficacy and potency of GABA action. For instance, bretazenil modulatory… Expand