Molecular mechanisms of the antitumor activity of SB225002: a novel microtubule inhibitor.

@article{Goda2013MolecularMO,
  title={Molecular mechanisms of the antitumor activity of SB225002: a novel microtubule inhibitor.},
  author={Ahmed E Goda and Makoto Koyama and Yoshihiro Sowa and Khaled M. Elokely and Tatsushi Yoshida and Bo Yeon Kim and Toshiyuki Sakai},
  journal={Biochemical pharmacology},
  year={2013},
  volume={85 12},
  pages={1741-52}
}
SB225002 (SB) is an IL-8 receptor B (IL-8RB) antagonist that has previously been shown to inhibit IL-8-based cancer cell invasion, and to possess in vivo anti-inflammatory and anti-nociceptive effects. The present study presented an evidence for the cell cycle-targeting activity of SB in a panel of p53-mutant human cancer cell lines of different origin, and investigated the underlying molecular mechanisms. A combination of cell cycle analysis, immunocytometry, immunoblotting, and RNA… CONTINUE READING
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