Molecular mechanisms of synaptic remodeling in alcoholism.

@article{Kyzar2015MolecularMO,
  title={Molecular mechanisms of synaptic remodeling in alcoholism.},
  author={Evan J Kyzar and Subhash C Pandey},
  journal={Neuroscience letters},
  year={2015},
  volume={601},
  pages={11-9}
}
Alcohol use and alcohol addiction represent dysfunctional brain circuits resulting from neuroadaptive changes during protracted alcohol exposure and its withdrawal. Alcohol exerts a potent effect on synaptic plasticity and dendritic spine formation in specific brain regions, providing a neuroanatomical substrate for the pathophysiology of alcoholism. Epigenetics has recently emerged as a critical regulator of gene expression and synaptic plasticity-related events in the brain. Alcohol exposure… CONTINUE READING
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