Molecular mechanisms of substrate recognition and specificity of New Delhi metallo-β-lactamase.

@article{Chiou2014MolecularMO,
  title={Molecular mechanisms of substrate recognition and specificity of New Delhi metallo-β-lactamase.},
  author={Jiachi Chiou and Thomas Yun-Chung Leung and Sheng Chen},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 9},
  pages={5372-8}
}
Carbapenems are one of the last lines of defense for Gram-negative pathogens, such as members of the Enterobacteriaceae. Despite the fact that most carbapenems are resistant to extended-spectrum β-lactamase (ESBL), emerging metallo-β-lactamases (MBLs), including New Delhi metallo-β-lactamase 1 (NDM-1), that can hydrolyze carbapenems have become prevalent… CONTINUE READING