Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception

  title={Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception},
  author={Donita J Africander and Nicolette J. D. Verhoog and Janet P Hapgood},
Synthetic progestins are used by millions of women as contraceptives and in hormone replacement therapy (HRT), although their molecular mechanisms of action are not well understood. The importance of investigating these mechanisms, as compared to those of progesterone, has been highlighted by clinical evidence showing that medroxyprogesterone acetate (MPA), a first generation progestin, increases the risk of breast cancer and coronary heart disease in HRT users. A diverse range of later… CONTINUE READING
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