• DOI:10.1016/j.steroids.2011.03.001
Corpus ID: 23630452

Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception

@article{Africander2011MolecularMO,
  title={Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception},
  author={D. Africander and N. Verhoog and J. Hapgood},
  journal={Steroids},
  year={2011},
  volume={76},
  pages={636-652}
}

• D. Africander, N. Verhoog, J. Hapgood
• Published 2011
• Medicine, Biology
• Steroids

Synthetic progestins are used by millions of women as contraceptives and in hormone replacement therapy (HRT), although their molecular mechanisms of action are not well understood. The importance of investigating these mechanisms, as compared to those of progesterone, has been highlighted by clinical evidence showing that medroxyprogesterone acetate (MPA), a first generation progestin, increases the risk of breast cancer and coronary heart disease in HRT users. A diverse range of later… Expand