Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception

@article{Africander2011MolecularMO,
  title={Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception},
  author={D. Africander and N. Verhoog and J. Hapgood},
  journal={Steroids},
  year={2011},
  volume={76},
  pages={636-652}
}
Synthetic progestins are used by millions of women as contraceptives and in hormone replacement therapy (HRT), although their molecular mechanisms of action are not well understood. The importance of investigating these mechanisms, as compared to those of progesterone, has been highlighted by clinical evidence showing that medroxyprogesterone acetate (MPA), a first generation progestin, increases the risk of breast cancer and coronary heart disease in HRT users. A diverse range of later… Expand
Potency of progestogens used in hormonal therapy: Toward understanding differential actions
Reciprocal Modulation of Antiretroviral Drug and Steroid Receptor Function In Vitro
A comparative study of the androgenic properties of progesterone and the progestins, medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A)
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