Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease.

@article{Barzilai2003MolecularMO,
  title={Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease.},
  author={Ari Barzilai and Eldad Melamed},
  journal={Trends in molecular medicine},
  year={2003},
  volume={9 3},
  pages={126-32}
}
Parkinson's disease (PD) is a progressive neurological disease caused by selective degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Although PD has been heavily researched, the precise etiology of nigral cell loss is still unknown and, consequently, treatment is largely symptomatic rather than preventive. There are conflicting data regarding the mode of dopaminergic cell death in PD and, hence, this remains controversial. Several mutations in specific genes have… CONTINUE READING

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