Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer.

  title={Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer.},
  author={Alberto Bardelli and Salvatore Siena},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={28 7},
Personalized cancer medicine based on the genetic milieu of individual colorectal tumors has long been postulated, but until recently this concept was not supported by clinical evidence. The advent of the epidermal growth factor receptor (EGFR) -targeted monoclonal antibodies cetuximab and panitumumab has paved the way to the individualized treatment of metastatic colorectal cancer (mCRC). Here we discuss the evidence that mCRCs respond differently to EGFR-targeted agents and that the tumor… CONTINUE READING
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