Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia

@article{Gorre2002MolecularMO,
  title={Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia},
  author={Mercedes E. Gorre and Charles L. Sawyers},
  journal={Current Opinion in Hematology},
  year={2002},
  volume={9},
  pages={303-307}
}
Therapeutic use of the recently FDA-approved drug STI571 has been successful in the treatment of Philadelphia chromosome–positive leukemias. STI571 is a small molecule inhibitor with activity against BCR-ABL, the deregulated tyrosine kinase responsible for initiation and maintenance of the disease in the chronic phase of chronic myeloid leukemia (CML). Clinical trials demonstrated the ability of STI571 to induce remissions in patients with chronic phase CML with only rare relapses after 18… 

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a 1-Acid glycoprotein expressed in the plasma of chronic myeloid leukemia patients does not mediate significant in vitro resistance to STI 571

In vitro findings suggest that AGP will not abrogate the antileukemic activity of STI571, and normal AGP, even at supraphysiological concentrations, did not block the effect of STi571 on K562-cell proliferation in vitro.

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