Molecular mechanisms of replicative senescence in endothelial cells.

  title={Molecular mechanisms of replicative senescence in endothelial cells.},
  author={Kimberly E. Foreman and Jun Tang},
  journal={Experimental gerontology},
  volume={38 11-12},
As human somatic cells age, they stop replicating and enter an irreversible state of growth arrest known as replicative senescence. Senescent cells are viable, metabolically active, and display altered gene and protein expression compared to proliferating cells. Endothelial cells, both in vitro and in vivo, are known to undergo senescence. As endothelial cells are a critical component of the vasculature, senescence of these cells can have a significant impact of vascular integrity, function… CONTINUE READING