Molecular mechanisms of remodeling in human atrial fibrillation.

  title={Molecular mechanisms of remodeling in human atrial fibrillation.},
  author={Bianca J. J. M. Brundel and Robert H. Henning and Harm H. Kampinga and Isabelle Van Gelder and Harry J. Crijns},
  journal={Cardiovascular research},
  volume={54 2},
An important acknowledgement of the last several years is that atrial fibrillation (AF) modifies the electrical properties of the atrium in a way that promotes its occurrence and maintenance. This arrhythmogenic electrophysiological remodeling is well established, but can not explain by itself that 'AF begets AF'. This review describes molecular changes involving rapid functional alterations and slower changes in protein expression that cause electrical remodeling and contractile dysfunction in… CONTINUE READING