Molecular mechanisms of pulmonary arterial hypertension: role of mutations in the bone morphogenetic protein type II receptor.

@article{Davies2008MolecularMO,
  title={Molecular mechanisms of pulmonary arterial hypertension: role of mutations in the bone morphogenetic protein type II receptor.},
  author={R J Davies and Nicholas W Morrell},
  journal={Chest},
  year={2008},
  volume={134 6},
  pages={
          1271-1277
        }
}
Pulmonary arterial hypertension (PAH) is characterized by abnormal remodeling of small, peripheral resistance vessels in the lung involving proliferation and migration of vascular smooth muscle, endothelial cell and fibroblasts. The increase in pulmonary vascular resistance leads to right heart failure, and, without treatment, death occurs within 3 years of diagnosis. The etiology of PAH is multifactorial. In some patients, there is a major genetic predisposition in the form of heterozygous… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 46 CITATIONS

Similar Papers

Loading similar papers…