Molecular mechanisms of protein kinase C-induced apoptosis in prostate cancer cells.

@article{GonzlezGuerrico2005MolecularMO,
  title={Molecular mechanisms of protein kinase C-induced apoptosis in prostate cancer cells.},
  author={Anatilde M. Gonz{\'a}lez-Guerrico and John Meshki and Liqing Xiao and Fernando Benavides and Claudio J. Conti and Marcelo G Kazanietz},
  journal={Journal of biochemistry and molecular biology},
  year={2005},
  volume={38 6},
  pages={639-45}
}
Protein kinase C (PKC) isozymes, a family of serine-threonine kinases, are important regulators of cell proliferation and malignant transformation. Phorbol esters, the prototype PKC activators, cause PKC translocation to the plasma membrane in prostate cancer cells, and trigger an apoptotic response. Studies in recent years have determined that each member of the PKC family exerts different effects on apoptotic or survival pathways. PKCdelta, one of the novel PKCs, is a key player of the… CONTINUE READING