Molecular mechanisms of prostate cancer.

  title={Molecular mechanisms of prostate cancer.},
  author={Kati P. Porkka and Tapio Visakorpi},
  journal={European urology},
  volume={45 6},
During the last ten years our knowledge of genetic alterations in prostate cancer has significantly increased. For example, several chromosomal loci possibly harboring predisposing or somatically mutated genes have been suggested. Still, we lack the comprehensive molecular model for the development and progression of prostate cancer. Only a few genes have been found to be aberrant in a significant proportion of prostate cancer. These include GSTP1, PTEN, TP53, and AR. Thus, they are natural… CONTINUE READING
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