Molecular mechanisms of normal iron homeostasis.

  title={Molecular mechanisms of normal iron homeostasis.},
  author={An-Sheng Zhang and Caroline A Enns},
  journal={Hematology. American Society of Hematology. Education Program},
Humans possess elegant control mechanisms to maintain iron homeostasis by coordinately regulating iron absorption, iron recycling, and mobilization of stored iron. Dietary iron absorption is regulated locally by hypoxia inducible factor (HIF) signaling and iron-regulatory proteins (IRPs) in enterocytes and systematically by hepatic hepcidin, the central iron regulatory hormone. Hepcidin not only controls the rate of iron absorption but also determines iron mobilization from stores through… CONTINUE READING

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  • I De Domenico, E Lo, DM Ward, J. Kaplan
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  • 2009
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