Molecular mechanisms of nociception

@article{Julius2001MolecularMO,
  title={Molecular mechanisms of nociception},
  author={David Julius and Allan I. Basbaum},
  journal={Nature},
  year={2001},
  volume={413},
  pages={203-210}
}
The sensation of pain alerts us to real or impending injury and triggers appropriate protective responses. Unfortunately, pain often outlives its usefulness as a warning system and instead becomes chronic and debilitating. This transition to a chronic phase involves changes within the spinal cord and brain, but there is also remarkable modulation where pain messages are initiated — at the level of the primary sensory neuron. Efforts to determine how these neurons detect pain-producing stimuli… Expand
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