Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung

@article{Persinger2004MolecularMO,
  title={Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung},
  author={Rebecca L. Persinger and Matthew E. Poynter and Karina Ckless and Yvonne M. W. Janssen-Heininger},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={234-235},
  pages={71-80}
}
The lung can be exposed to a variety of reactive nitrogen intermediates through the inhalation of environmental oxidants and those produced during inflammation. Reactive nitrogen species (RNS) include, nitrogen dioxide (·NO2) and peroxynitrite (ONOO–). Classically known as a major component of both indoor and outdoor air pollution, ·NO2 is a toxic free radical gas. ·NO2 can also be formed during inflammation by the decomposition of ONOO– or through peroxidase-catalyzed reactions. Due to their… 
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TLDR
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The most recent data, besides confirming the mitochondrial role in tissue oxidative stress and protection, show interplay between mitochondria and other ROS cellular sources, so that activation of one can lead to activation of other sources.
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