Molecular mechanisms of neutrophil-endothelial cell adhesion induced by redox imbalance.

@article{Kokura1999MolecularMO,
  title={Molecular mechanisms of neutrophil-endothelial cell adhesion induced by redox imbalance.},
  author={S Kokura and Robert E. Wolf and Toshikazu Yoshikawa and Dr. D. Neil Granger and Tak Yee Aw},
  journal={Circulation research},
  year={1999},
  volume={84 5},
  pages={516-24}
}
Previous studies have implicated a role for intracellular thiols in the activation of nuclear factor-kappaB and transcriptional regulation of endothelial cell adhesion molecules. This study was designed to determine whether changes in endothelial cell glutathione (GSH) or oxidized glutathione (GSSG) can alter neutrophil adhesivity and to define the molecular mechanism that underlies this GSSG/GSH-induced adhesion response. Treatment of human umbilical vein endothelial cell (HUVEC) monolayers… CONTINUE READING
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