Molecular mechanisms of anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells.

@article{Ichikawa1997MolecularMO,
  title={Molecular mechanisms of anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells.},
  author={Hiroshi T. Ichikawa and Sonia Flores and Peter R. Kvietys and Robert E. Wolf and Toshikazu Yoshikawa and Dr. D. Neil Granger and Tak Yee Aw},
  journal={Circulation research},
  year={1997},
  volume={81 6},
  pages={922-31}
}
The objectives of this study were to (1) determine the time course of neutrophil adhesion to monolayers of human umbilical vein endothelial cells (HUVECs) that were exposed to 60 minutes of anoxia followed by 30 to 600 minutes of reoxygenation and (2) define the mechanisms responsible for both the early (minutes) and late (hours) hyperadhesivity of postanoxic HUVECs to human neutrophils. The results clearly demonstrate that anoxia/reoxygenation (A/R) leads to a biphasic increase in neutrophil… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 59 extracted citations

Similar Papers

Loading similar papers…