Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine

@article{McEwen2004MolecularMO,
  title={Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine},
  author={Bruce S. McEwen and Sumantra Chattarji},
  journal={European Neuropsychopharmacology},
  year={2004},
  volume={14},
  pages={S497-S502}
}
Neurobiological and Clinical Effects of the Antidepressant Tianeptine
TLDR
The neurobiological properties of tianeptine may provide an explanation not only for its antidepressant activity, but also for its anxiolytic effects in depressed patients and its lack of adverse effects on cognitive function and memory.
The ever‐changing brain: Cellular and molecular mechanisms for the effects of stressful experiences
  • B. McEwen
  • Biology
    Developmental neurobiology
  • 2012
The adult brain is capable of considerable structural and functional plasticity and the study of hormone actions in brain has contributed to our understanding of this important phenomenon. In
Neuroplasticity and major depression, the role of modern antidepressant drugs.
  • G. Serafini
  • Psychology, Biology
    World journal of psychiatry
  • 2012
TLDR
The neuroplasticity hypothesis may explain the therapeutic and prophylactic action of ADs representing a new innovative approach to the pathophysiology of depression and stress-related disorders.
Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling
  • B. McEwen
  • Biology, Psychology
    Annals of the New York Academy of Sciences
  • 2010
TLDR
This review will illustrate the actions of estrogen on synapse formation in the hippocampus and the process of stress‐induced remodeling of dendrites and synapses in the hippocamp, amygdala, and prefrontal cortex.
Modulation of stress consequences by hippocampal monoaminergic, glutamatergic and nitrergic neurotransmitter systems
TLDR
The hippocampal formation contains a high concentration of corticoid receptors and undergoes plastic modifications, including decreased neurogenesis and cellular remodelling, following stress exposure, and various major neurotransmitter systems in the hippocampus are involved in these effects.
Repeated stress and structural plasticity in the brain
Tianeptine: An Antidepressant with Memory-Protective Properties
TLDR
Findings indicate that tianeptine accomplishes its anti-stress effects by normalizing stress-induced increases in glutamate in the hippocampus and amygdala, which is potentially relevant to recent research which indicates that abnormalities in glutamatergic neurotransmission are involved in the pathogenesis of depression.
Tianeptine increases brain-derived neurotrophic factor expression in the rat amygdala.
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