Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine

@article{McEwen2004MolecularMO,
  title={Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine},
  author={B. McEwen and S. Chattarji},
  journal={European Neuropsychopharmacology},
  year={2004},
  volume={14},
  pages={s497-s502}
}
The hippocampal formation, which expresses high levels of adrenal steroid receptors, is a malleable brain structure that is important for certain types of learning and memory. This structure is also vulnerable to the effects of stress hormones which have been reported to be increased in depressed patients, particularly those with severe depression. The amygdala, a structure that plays a critical role in fear learning, is also an important target of anxiety and stress. Certain animal models of… Expand
159 Citations
Neurobiological and Clinical Effects of the Antidepressant Tianeptine
  • 124
  • PDF
The ever‐changing brain: Cellular and molecular mechanisms for the effects of stressful experiences
  • B. McEwen
  • Biology, Medicine
  • Developmental neurobiology
  • 2012
  • 123
Neuroplasticity and major depression, the role of modern antidepressant drugs.
  • 46
Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling
  • B. McEwen
  • Psychology, Medicine
  • Annals of the New York Academy of Sciences
  • 2010
  • 291
Repeated stress and structural plasticity in the brain
  • 216
  • PDF
Tianeptine: An Antidepressant with Memory-Protective Properties
  • 32
  • PDF
Stress and anxiety: Structural plasticity and epigenetic regulation as a consequence of stress
  • 403
  • PDF
Tianeptine increases brain-derived neurotrophic factor expression in the rat amygdala.
  • 59
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 58 REFERENCES
Stress and hippocampal plasticity.
  • B. McEwen
  • Psychology, Medicine
  • Annual review of neuroscience
  • 1999
  • 1,893
  • PDF
Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
  • 1,037
  • PDF
Neurotransmission in the rat amygdala related to fear and anxiety
  • 724
  • PDF
Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac)
  • 211
  • PDF
Neuroimaging studies of mood disorders
  • W. Drevets
  • Psychology, Medicine
  • Biological Psychiatry
  • 2000
  • 1,249
  • PDF
...
1
2
3
4
5
...