Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine
@article{McEwen2004MolecularMO,
title={Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine},
author={Bruce S. McEwen and Sumantra Chattarji},
journal={European Neuropsychopharmacology},
year={2004},
volume={14},
pages={S497-S502}
}165 Citations
Neurobiological and Clinical Effects of the Antidepressant Tianeptine
- Psychology, BiologyCNS drugs
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The neurobiological properties of tianeptine may provide an explanation not only for its antidepressant activity, but also for its anxiolytic effects in depressed patients and its lack of adverse effects on cognitive function and memory.
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This review will illustrate the actions of estrogen on synapse formation in the hippocampus and the process of stress‐induced remodeling of dendrites and synapses in the hippocamp, amygdala, and prefrontal cortex.
Modulation of stress consequences by hippocampal monoaminergic, glutamatergic and nitrergic neurotransmitter systems
- Biology, PsychologyStress
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The hippocampal formation contains a high concentration of corticoid receptors and undergoes plastic modifications, including decreased neurogenesis and cellular remodelling, following stress exposure, and various major neurotransmitter systems in the hippocampus are involved in these effects.
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Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon
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Tianeptine: An Antidepressant with Memory-Protective Properties
- Psychology, BiologyCurrent neuropharmacology
- 2008
Findings indicate that tianeptine accomplishes its anti-stress effects by normalizing stress-induced increases in glutamate in the hippocampus and amygdala, which is potentially relevant to recent research which indicates that abnormalities in glutamatergic neurotransmission are involved in the pathogenesis of depression.
Stress and anxiety: Structural plasticity and epigenetic regulation as a consequence of stress
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Tianeptine increases brain-derived neurotrophic factor expression in the rat amygdala.
- Biology, PsychologyEuropean journal of pharmacology
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