Molecular mechanisms of neuronal migration disorders, quo vadis?

  title={Molecular mechanisms of neuronal migration disorders, quo vadis?},
  author={Sebastien Couillard-Despres and J{\"u}rgen Winkler and Goekhan Uyanik and Ludwig Aigner},
  journal={Current molecular medicine},
  volume={1 6},
Following terminal mitosis, neuronal precursor cells leave their site of origin and migrate towards their definitive site of residency. In order to establish the intricate cytoarchitecture described in the adult human brain, neuronal migration must be finely regulated. In humans, brain malformations can result from neuronal migration defects. The spectrum of migration disorder severity extends from few heterotopic neurons, as observed in periventricular heterotopia, to a complete cortical… CONTINUE READING