Molecular mechanisms of necroptosis: an ordered cellular explosion

  title={Molecular mechanisms of necroptosis: an ordered cellular explosion},
  author={Peter Vandenabeele and Lorenzo Galluzzi and Tom Vanden Berghe and Guido Kroemer},
  journal={Nature Reviews Molecular Cell Biology},
For a long time, apoptosis was considered the sole form of programmed cell death during development, homeostasis and disease, whereas necrosis was regarded as an unregulated and uncontrollable process. Evidence now reveals that necrosis can also occur in a regulated manner. The initiation of programmed necrosis, 'necroptosis', by death receptors (such as tumour necrosis factor receptor 1) requires the kinase activity of receptor-interacting protein 1 (RIP1; also known as RIPK1) and RIP3 (also… 

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[The molecular mechanism of necroptosis].

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This review will focus on the intracellular and intercellular signaling events in necrosis induced by different stimuli, such as oxidative stress, cytokines and pathogen-associated molecular patterns (PAMPs), which can be linked to several pathologies such as stroke, cardiac failure, neurodegenerative diseases, and infections.

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