Molecular mechanisms of muscle atrophy in myotonic dystrophies.

  title={Molecular mechanisms of muscle atrophy in myotonic dystrophies.},
  author={Lubov T. Timchenko},
  journal={The international journal of biochemistry & cell biology},
  volume={45 10},
Myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2) are multisystemic diseases that primarily affect skeletal muscle, causing myotonia, muscle atrophy, and muscle weakness. DM1 and DM2 pathologies are caused by expansion of CTG and CCTG repeats in non-coding regions of the genes encoding myotonic dystrophy protein kinase (DMPK) and zinc finger protein 9 (ZNF9) respectively. These expansions cause DM pathologies through accumulation of mutant RNAs that alter RNA metabolism in… CONTINUE READING

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