Molecular mechanisms of microvascular failure in central nervous system injury--synergistic roles of NKCC1 and SUR1/TRPM4.

@article{Simard2010MolecularMO,
  title={Molecular mechanisms of microvascular failure in central nervous system injury--synergistic roles of NKCC1 and SUR1/TRPM4.},
  author={J. Marc Simard and Kristopher Thomas Kahle and Volodymyr Gerzanich},
  journal={Journal of neurosurgery},
  year={2010},
  volume={113 3},
  pages={622-9}
}
Microvascular failure largely underlies the damaging secondary events that accompany traumatic brain injury (TBI). Changes in capillary permeability result in the extravasation of extracellular fluid, inflammatory cells, and blood, thereby producing cerebral edema, inflammation, and progressive secondary hemorrhage (PSH). Recent work in rat models of TBI and stroke have implicated 2 ion transport proteins expressed in brain endothelial cells as critical mediators of edema formation: the… CONTINUE READING
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